How are fluctuating estrogen levels linked to autoimmune disease prevalence and what mechanisms underlie its protective or harmful effects in these conditions?
Gaurav ChauhanContributor
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How are fluctuating estrogen levels linked to autoimmune disease prevalence and what mechanisms underlie its protective or harmful effects in these conditions?
Fluctuating estrogen levels can modulate immune system activity, potentially influencing autoimmune disease. Estrogen generally has an immunoenhancing effect at moderate levels, which could exacerbate conditions like lupus, but may also protect against others like rheumatoid arthritis by reducing inflammation.
Estrogen can modulate immune response, enhancing or suppressing it. High levels generally protect against autoimmune diseases by reducing inflammatory responses.