What role does Metformin play in reducing or influencing inflammatory markers in systemic conditions and how might this contribute to its broader health benefits?
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Can Metformin be effectively used as an adjunct treatment for managing hormonal acne linked to insulin resistance and how does it address the underlying metabolic and hormonal imbalances?
Are there instances where Metformin use leads to localized swelling in the hands or feet and what underlying mechanisms might cause this reaction?
How does Metformin interact with herbal supplements like cinnamon or berberine, which are often used for blood sugar control and are there potential risks or benefits?
Is Metformin considered safe and effective for patients with gout and how might it impact uric acid levels or related symptoms in these individuals?
What role does Metformin play in influencing the long-term risk of cancer recurrence in patients with a history of cancer and what evidence supports these effects?
Does Metformin use contribute to fatigue or general feelings of weakness in patients and what are the potential mechanisms or contributing factors for these symptoms?
How does Metformin modulate immune system responses in the body and are there potential benefits or risks associated with its immunological effects?
How is Metformin utilized in managing broader symptoms of metabolic syndrome beyond blood sugar control and what additional health benefits might it provide?
Does Metformin have any impact on oxygen delivery or levels in the bloodstream during physical activity and how might this affect endurance or exercise capacity?