Combining diclofenac with corticosteroids increases the risk of gastrointestinal ulcers and bleeding. To reduce risks, use the lowest effective doses for the shortest duration.

Using diclofenac with corticosteroids may elevate the risk of kidney issues. Monitoring kidney function and maintaining proper hydration can help minimize this risk.

Concurrent use of diclofenac and corticosteroids can heighten the potential for weakened immune response. Limiting exposure to pathogens and regular health checks can mitigate this risk.