What are the pharmacokinetics of diclofenac in the human body, including absorption, metabolism and excretion and how do these factors influence its effectiveness and safety?
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What are the pharmacokinetics of diclofenac in the human body, including absorption, metabolism and excretion and how do these factors influence its effectiveness and safety?
Diclofenac is quickly absorbed after oral administration, with peak plasma concentrations attained in 1 to 2 hours. It undergoes extensive hepatic metabolism, primarily by cytochrome P450 enzymes, and is eliminated predominantly via renal pathways. This pharmacokinetic profile influences both its therapeutic effectiveness and risk of hepatic and renal side effects.