What are the primary contraindications for using Metformin and in which health conditions should its use be avoided or closely monitored?
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What are the primary contraindications for using Metformin and in which health conditions should its use be avoided or closely monitored?
1. Metformin is contraindicated in renal failure, acute heart failure, and liver disease, due to the risk of lactic acidosis.
2. Avoid Metformin in patients with severe kidney impairment, acute or chronic metabolic acidosis, including diabetic ketoacidosis, and those with severe dehydration.
3. Metformin use should be avoided in individuals with severe liver disease, alcoholism, or any condition associated with hypoxemia, due to increased lactic acidosis risk.
4. Severe renal dysfunction, hypersensitivity to Metformin, and acute conditions that affect kidney function (like dehydration) are primary contraindications for its use.
1. Metformin is contraindicated in patients with renal disease or dysfunction, as it can increase the risk of lactic acidosis.
2. Avoid metformin in severe liver disease due to the risk of lactic acidosis and impaired drug clearance.
3. Metformin should not be used in those with severe respiratory disease, as it may exacerbate metabolic acidosis.
4. In patients with a history of heart failure requiring drug therapy, metformin use should be avoided or closely monitored.
5. Metformin is contraindicated in individuals with acute or chronic metabolic acidosis, including diabetic ketoacidosis.