How does Sitagliptin improve postprandial blood glucose regulation, and what mechanisms contribute to its effectiveness in managing hyperglycemia after meals?
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How does Sitagliptin improve blood glucose regulation in post-meal hyperglycemia?
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Sitagliptin, a DPP-4 inhibitor, enhances incretin hormones, which increase insulin production and decrease glucagon release post-meal, improving glucose control.
By inhibiting the enzyme DPP-4, Sitagliptin prolongs incretin activity, promoting insulin release and decreasing glucagon to stabilize postprandial glucose levels.