How does Sitagliptin affect incretin hormone dynamics in the gut, and what are the implications for glucose regulation and appetite control?
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How does Sitagliptin affect incretin hormone dynamics in the gut, and what are the implications for glucose regulation and appetite control?
Sitagliptin inhibits DPP-4, enhancing incretin levels (GLP-1, GIP), which boosts insulin secretion, lowers glucagon, and aids glucose regulation, also potentially reducing appetite.