What is the detailed mechanism of action of methyldopa in lowering blood pressure, including its role in inhibiting sympathetic outflow and reducing vascular tone?
Lakshya KumarExplorer
What is the mechanism of action of methyldopa in lowering blood pressure?
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Methyldopa is a prodrug converted to alpha-methyl norepinephrine in the brain, which replaces norepinephrine at central adrenergic receptors, decreasing sympathetic outflow and vascular tone.