Diclofenac may elevate liver enzymes, affecting lipid and glucose metabolism. Monitoring liver function tests periodically is advised to manage these effects.

Diclofenac use could lead to altered lipid profiles and glucose levels. Regular monitoring and adjusting diabetes or lipid-lowering medications may be necessary.

In some patients, diclofenac can disrupt normal lipid and glucose processing, potentially raising levels. Healthcare providers usually manage this with diet adjustments and regular blood tests.