What are the potential drug interactions with Atorvastatin, and how can clinicians reduce risks when prescribing it with other medications?
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What are the potential drug interactions with Atorvastatin, and how can clinicians reduce risks when prescribing it with other medications?
1. Atorvastatin may interact with grapefruit juice, warfarin, and some antibiotics. Clinicians should monitor INR levels and avoid combining it with high-risk drugs.
2. Atorvastatin can increase the effects of anticoagulants and some BP meds. Regular liver function tests and avoiding high-risk combinations can reduce interaction risks.
3. Combining atorvastatin with certain antifungals or HIV drugs can raise its blood levels, risking toxicity. Dose adjustments and close monitoring can mitigate these risks.
4. Atorvastatin interactions with macrolide antibiotics or calcium channel blockers can elevate statin levels, risking myopathy. Clinicians should consider alternative antibiotics or monitor closely.
5. Co-administration of atorvastatin with cyclosporine or gemfibrozil can increase statin toxicity. Alternative medications or dosage adjustments are recommended to manage risk.