What are the pharmacological differences between methyldopa and ACE inhibitors for hypertension management and which patient populations benefit most from each?
Lakshya KumarExplorer
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Methyldopa, a central alpha-2 agonist, reduces blood pressure by decreasing sympathetic outflow, ideal for pregnant patients. ACE inhibitors block angiotensin-II formation, benefiting those with heart failure or diabetes.
Methyldopa acts on the central nervous system to lower blood pressure and is preferred in pregnancy. ACE inhibitors prevent blood vessel constriction, beneficial for heart failure and kidney protection.