Long-term use of Rosuvastatin in high-risk patients may increase risks of diabetes and muscle damage. Regular monitoring of blood sugar and CK levels can help mitigate these risks.

Prolonged Rosuvastatin therapy in high-risk individuals requires consistent liver function tests and consideration of dose adjustments based on kidney health to minimize severe side effects.

For high-risk patients, long-term Rosuvastatin could lead to liver issues and myopathy. Risk minimization involves periodic liver enzyme checks and monitoring for muscle symptoms.