What are the guidelines for using Valium in patients undergoing dialysis, and how does impaired renal function impact its dosing and metabolism?
Gaurav ChauhanContributor
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What are the guidelines for using Valium in patients undergoing dialysis, and how does impaired renal function impact its dosing and metabolism?
Valium (diazepam) is metabolized by the liver, so renal impairment has less impact on its clearance. However, caution is advised due to the potential for enhanced effects and longer half-life in dialysis patients.
Diazepam (Valium) is metabolized hepatically and its active metabolites rely on renal excretion. In dialysis patients, dose adjustments may be necessary to prevent accumulation and toxicity.
Valium usage in dialysis patients requires caution, as renal impairment can lead to accumulation of its metabolites, prolonging its effect. Dosage reduction is recommended to avoid adverse effects.