What are the effects of Metoclopramide on neurotransmitter activity, particularly dopamine and serotonin and how do these changes influence its therapeutic and side effect profiles?
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What are the effects of Metoclopramide on neurotransmitter activity, particularly dopamine and serotonin and how do these changes influence its therapeutic and side effect profiles?
Metoclopramide blocks dopamine receptors, reducing nausea but increasing the risk of movement disorders. It also enhances serotonin action, aiding gastric emptying but sometimes causing diarrhea.