What effects does insulin have on autophagy in pancreatic beta cells, and how does this process impact long-term beta-cell function?
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What effects does insulin have on autophagy in pancreatic beta cells, and how does this process impact long-term beta-cell function?
1. Insulin suppresses autophagy in pancreatic beta cells, aiding cell survival and function but prolonged inhibition can lead to cell stress and dysfunction.
2. Insulin inhibits autophagy in beta cells, which initially protects them but prolonged inhibition can reduce their ability to regenerate, impairing long-term function.