What are the key differences between oral and topical progesterone applications in terms of absorption, efficacy, side effects and suitability for different medical conditions?
Gaurav ChauhanContributor
What are the differences between oral and topical progesterone applications?
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Oral progesterone can be less effective due to liver metabolism reducing its bioavailability. Topical forms bypass the liver, offering better absorption and fewer side effects.
Oral progesterone can be less effective due to first-pass metabolism in the liver, whereas topical application bypasses the liver, potentially reducing side effects.