1. In patients with renal impairment, sitagliptin doses should be adjusted based on eGFR. For moderate impairment, reduce dose to 50 mg daily; for severe, 25 mg daily.

2. For renal impairment, monitor sitagliptin closely. Prescribe 50 mg/day for eGFR 30-49 mL/min/1.73 m² and 25 mg/day if eGFR is less than 30.

3. Dose adjustments for sitagliptin in renal impairment are crucial. Decrease to 50 mg for moderate and 25 mg for severe impairment, guided by regular kidney function assessments.