1. Regular monitoring of clotting parameters like aPTT and ACT is essential for optimal dosing of anticoagulants.
2. Use of continuous infusion of unfractionated heparin, guided by frequent coagulation tests, helps maintain target anticoagulation.
3. Ensure balanced anticoagulation to minimize bleeding risks while preventing circuit clotting, adjusting based on clinical observations.
4. Incorporate a multidisciplinary approach including specialists in hematology for managing complex anticoagulation scenarios.