Does Metoprolol interact with over-the-counter sleep aids, and could this combination increase sedation or other side effects like fatigue?
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Yes, Metoprolol may interact with some OTC sleep aids containing antihistamines, potentially increasing drowsiness, dizziness, and fatigue.
Combining Metoprolol with diphenhydramine (a common OTC sleep aid) can heighten side effects like sedation and dizziness due to additive CNS depressant effects.