How is tramadol metabolized in the body and what factors, such as genetics or co-existing conditions, influence its metabolism?
Lakshya KumarExplorer
How is tramadol metabolized in the body and what factors influence its metabolism?
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Tramadol is primarily metabolized by liver enzymes CYP2D6 and CYP3A4 into active metabolite O-desmethyltramadol. Genetic variations in CYP2D6 can affect its metabolism, impacting efficacy and risk of side effects.