How is Losartan metabolized in the body, and what role do the liver and kidneys play in processing the medication to ensure it reaches therapeutic levels without causing harm?
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How is Losartan metabolized in the body, and what role do the liver and kidneys play in processing the medication to ensure it reaches therapeutic levels without causing harm?
Losartan is metabolized in the liver by cytochrome P450 enzymes, primarily CYP2C9, into its active metabolite. The kidneys aid in excreting metabolites and maintaining therapeutic levels.