How does Sitagliptin enhance insulin secretion in advanced diabetes, particularly in patients with significant beta-cell dysfunction?
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How does Sitagliptin enhance insulin secretion in advanced diabetes, particularly in patients with significant beta-cell dysfunction?
Sitagliptin inhibits the enzyme DPP-4, increasing GLP-1 levels, which enhances insulin secretion and decreases glucagon release, improving glycemic control even with beta-cell dysfunction.