How does Sitagliptin promote beta-cell survival under oxidative stress, and what are its implications for preserving insulin secretion?
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How does Sitagliptin promote beta-cell survival under oxidative stress, and what are its implications for preserving insulin secretion?
Sitagliptin reduces oxidative stress in beta cells by inhibiting DPP-4, enhancing GLP-1 levels, which in turn boosts insulin secretion and cell survival. This may improve glycemic control in diabetics.