How does Sitagliptin affect glucose metabolism in the pancreas, and what are the mechanisms behind its regulation of insulin and glucagon secretion?
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How does Sitagliptin affect glucose metabolism in the pancreas, and what are the mechanisms behind its regulation of insulin and glucagon secretion?
Sitagliptin, a DPP-4 inhibitor, enhances glucagon-like peptide-1 (GLP-1) levels, boosting insulin synthesis and release, and reducing glucagon secretion when glucose levels are high.