Rosuvastatin effectively lowers LDL and total cholesterol, more than omega-3s, which are better for increasing HDL and reducing triglycerides. Rosuvastatin can cause muscle pain, unlike omega-3s, which may cause fishy burps.

Omega-3 fatty acids mainly reduce triglycerides and are gentle, while Rosuvastatin robustly decreases LDL cholesterol but may lead to side effects like muscle aches and liver issues.