How does renal impairment affect insulin metabolism and dosing, and what precautions should be taken for diabetic patients with kidney disease?
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1. Renal impairment slows insulin clearance, raising the risk of hypoglycemia. Diabetics with kidney disease should have their insulin doses adjusted and monitored closely.
2. In patients with renal failure, decreased insulin degradation can lead to prolonged insulin action and a higher risk for hypoglycemia, necessitating careful dose adjustments.
3. Kidney dysfunction can impair insulin excretion, increasing hypoglycemia risk. It’s crucial for diabetics to adjust insulin doses based on renal function tests.
4. With renal impairment, reduced insulin clearance can increase the risk of low blood sugar. Regular monitoring of kidney function and adjusting insulin doses accordingly is essential for diabetic patients.