How does ranitidine impact the renal system, including its influence on kidney filtration rates or electrolyte balance, in patients with varying levels of renal function?
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Ranitidine is primarily metabolized in the liver, but it’s excreted by the kidneys. In patients with impaired renal function, ranitidine’s elimination is reduced, potentially increasing the risk of toxicity.
Ranitidine may alter kidney filtration rates by affecting renal blood flow. In renal impairment, careful dosing is crucial to avoid accumulation and potential adverse effects.
In renal patients, ranitidine use requires caution. It can decrease renal clearance and alter electrolyte balance, necessitating regular monitoring of kidney function.