How does omeprazole interact with SSRIs, such as fluoxetine, in GERD patients and what precautions should be taken when prescribing both medications together?
Lakshya KumarExplorer
How does omeprazole interact with SSRIs, such as fluoxetine, in GERD patients?
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Omeprazole may increase serum levels of SSRIs like fluoxetine by inhibiting CYP2C19, an enzyme that metabolizes SSRIs. This can enhance SSRI side effects. Monitor patients for increased SSRI effects.