How does nitrofurantoin affect individuals with renal impairment and what adjustments in dosing or monitoring are necessary to ensure safety and efficacy?
IVF Questions & Answers
Sign Up to our social questions and Answers Engine to ask questions, answer people’s questions, and connect with other people.
Please briefly explain why you feel this question should be reported.
Please briefly explain why you feel this answer should be reported.
Please briefly explain why you feel this user should be reported.
How does nitrofurantoin affect individuals with renal impairment and what adjustments in dosing or monitoring are necessary to ensure safety and efficacy?
Nitrofurantoin is contraindicated in patients with a creatinine clearance below 60 mL/min due to inadequate urinary concentrations and risk of toxicity. Monitoring kidney function is crucial.
In individuals with renal impairment, nitrofurantoin’s clearance decreases, potentially increasing toxicity. Dosage adjustments are necessary, and alternative antibiotics may be preferred for CrCl <60 mL/min.
Due to reduced drug excretion, nitrofurantoin can build up in patients with poor renal function, increasing toxicity risks. It should be avoided if CrCl is under 60 mL/min, with regular renal monitoring advised.