How does methyldopa affect the synthesis and release of norepinephrine in the central nervous system and what are the implications for blood pressure control?
Lakshya KumarExplorer
How does methyldopa affect the synthesis and release of norepinephrine in the central nervous system?
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Methyldopa inhibits dopamine beta-hydroxylase, reducing norepinephrine synthesis. This diminishes sympathetic nervous system activity and lowers blood pressure.
Methyldopa is converted into alpha-methyl norepinephrine in the CNS, which acts as a false transmitter and reduces norepinephrine release, lowering blood pressure.