How does magnesium sulfate interact with other medications and what are the implications for polypharmacy or combination therapies?
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How does magnesium sulfate interact with other medications and what are the implications for polypharmacy or combination therapies?
Magnesium sulfate may reduce the effectiveness of certain antibiotics like tetracyclines and increase the potency of neuromuscular blockers, complicating polypharmacy.
Combining magnesium sulfate with diuretics can enhance the risk of magnesium toxicity, especially in renal impairment, necessitating careful monitoring.
When used with digoxin, magnesium sulfate can heighten the risk of toxicity; it is imperative to monitor serum levels closely in such combinations.
Magnesium sulfate can interfere with the absorption of bisphosphonates, requiring a time gap between administrations to ensure efficacy.
Taking magnesium sulfate with calcium channel blockers may lead to an additive effect on blood pressure, necessitating adjustments and close monitoring.