Loratadine is metabolized in the liver and excreted by the kidneys. For patients with liver or kidney impairment, a lower initial dose is recommended to prevent accumulation.

In patients with liver or kidney issues, loratadine should be used cautiously. Dosing adjustments may be necessary, generally starting at a lower dose to avoid high blood levels.

For those with renal or hepatic impairment, loratadine’s dosage may need reduction. Monitoring for adverse effects is advisable, given potential for increased drug levels.

Patients with compromised liver or kidney function should start loratadine at a reduced dose, as their ability to process and clear the drug is diminished.