How does leuprolide function as a gonadotropin-releasing hormone receptor agonist, and what are the molecular and physiological mechanisms underlying its effects on hormonal regulation?
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How does leuprolide function as a gonadotropin-releasing hormone receptor agonist, and what are the molecular and physiological mechanisms underlying its effects on hormonal regulation?
Leuprolide functions as a GnRH agonist by initially stimulating the pituitary to release LH and FSH, which leads to a temporary increase in sex hormones. Over time, continuous stimulation results in receptor downregulation and reduced hormone production.
Leuprolide, a GnRH agonist, initially boosts FSH and LH release, subsequently reducing them through receptor downregulation, diminishing sex hormone synthesis.