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How does leuprolide compare to newer GnRH antagonists in terms of treatment efficacy, safety profiles, and patient outcomes across various clinical applications, including fertility management and cancer treatment?
Leuprolide, a GnRH agonist, is effective in prostate cancer and endometriosis but causes initial hormone flare. Newer GnRH antagonists have quicker action, avoid flare-ups, and offer similar efficacy with potentially better safety profiles in managing fertility and cancer.
Leuprolide shows similar efficacy in suppressing hormone levels compared to newer GnRH antagonists but often has a slower onset of action and may cause more initial hormone flare-ups.