How does Leuprolide affect the pituitary gland’s secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and what are the downstream effects on gonadal function?
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How does Leuprolide affect the pituitary gland’s secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and what are the downstream effects on gonadal function?
Leuprolide initially increases LH and FSH release by stimulating the pituitary, then causes desensitization, reducing their levels and suppressing gonadal hormone production.
Leuprolide, a GnRH agonist, initially increases LH and FSH production, causing a surge in hormone levels. Prolonged use leads to receptor desensitization in the pituitary, reducing LH and FSH secretion and subsequently suppressing gonadal steroidogenesis.