How does Leuprolide administration impact testosterone flare in prostate cancer treatment, and what strategies are used to mitigate this transient increase in hormone levels?
Gaurav ChauhanContributor
How does Leuprolide administration impact testosterone flare in prostate cancer?
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Leuprolide can cause a temporary testosterone surge (flare) in prostate cancer patients. To counteract this, antiandrogens like bicalutamide are prescribed before starting leuprolide.
Leuprolide initially increases testosterone, causing a “flare.” Antiandrogens are often used to prevent this effect and mitigate symptoms.