Labetalol may reduce the absorption of drugs like cimetidine, impacting their effectiveness. Monitoring and dosage adjustments are essential when used together.

Combining labetalol with antacids can decrease its bioavailability, potentially necessitating dosage adjustments to maintain blood pressure control.

When labetalol is used with gastrointestinal prokinetics like metoclopramide, there could be enhanced absorption of labetalol, requiring careful monitoring of blood pressure.