How does ibuprofen affect the pharmacokinetics of other drugs and are there particular concerns with medications that have a narrow therapeutic index?
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How does ibuprofen affect the pharmacokinetics of other drugs and are there particular concerns with medications that have a narrow therapeutic index?
Ibuprofen can inhibit CYP2C9 enzyme, potentially slowing the metabolism of drugs metabolized by this pathway and raising their blood levels, which is a concern for drugs with a narrow therapeutic index.