Diphenhydramine often causes more sedation than hydroxyzine, but both are effective for allergies. Hydroxyzine may have better patient tolerability due to fewer side effects.

Both medications treat allergies effectively; however, diphenhydramine typically induces greater sedation and sometimes more side effects, which can affect tolerability compared to hydroxyzine.

Hydroxyzine is generally less sedating than diphenhydramine and may be better tolerated, making it a preferred option for long-term management of allergy symptoms.

While both are effective, diphenhydramine may cause more drowsiness. Patients often tolerate hydroxyzine better due to its milder sedative effects.