How does bacterial resistance to nitrofurantoin develop and what are the implications for its continued use as a first-line treatment for UTIs?
Lakshya KumarExplorer
How does bacterial resistance to nitrofurantoin develop and what are the implications?
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Bacterial resistance to nitrofurantoin develops through genetic mutations that enhance bacterial enzymes or efflux pumps, reducing drug efficacy. This resistance could limit its effectiveness in treating UTIs if trends continue.