Atorvastatin can enhance the effect of antihypertensive drugs, reducing blood pressure further. It may also increase the risk of bleeding when combined with anticoagulants like warfarin.

Atorvastatin can raise blood levels of some medications, such as digoxin, requiring close monitoring of digoxin levels to avoid toxicity.

Concurrent use of atorvastatin and certain calcium channel blockers, like amlodipine, may increase the risk of muscle-related side effects, necessitating dose adjustments.