How do vitamin K antagonists, such as warfarin, work to inhibit clot formation, and what are the common indications for their use?
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How do vitamin K antagonists, such as warfarin, work to inhibit clot formation, and what are the common indications for their use?
Vitamin K antagonists like warfarin inhibit clot formation by blocking the synthesis of coagulation factors II, VII, IX, and X in the liver. They are used to prevent thrombosis in conditions like atrial fibrillation, and after thromboembolic events such as pulmonary embolism or deep vein thrombosis.