In clinics, cases of unexplained infertility in couples pursuing In-Vitro Fertilization (IVF) are typically approached with a comprehensive diagnostic evaluation to identify any underlying factors contributing to the infertility. This process often involves the following steps:

1. Thorough Medical History: The medical history of both partners will be carefully reviewed to identify any potential factors that could be contributing to infertility.

2. Physical Examination: A physical examination may be conducted to identify any visible signs of infertility issues.

3. Hormone Testing: Blood tests may be done to evaluate hormone levels, which can provide insights into ovulation, egg quality, and other factors related to fertility.

4. Semen Analysis: The male partner will undergo semen analysis to assess sperm count, motility, and morphology.

5. Ovarian Reserve Testing: This involves assessing the quantity and quality of a woman’s eggs through tests such as antral follicle count and anti-Müllerian hormone (AMH) levels.

6. Hysterosalpingography (HSG): This test allows the doctor to evaluate the shape of the uterine cavity and the patency of the fallopian tubes.

7. Laparoscopy: In some cases, a laparoscopy may be performed to assess the pelvic organs and look for any signs of endometriosis or other abnormalities.

Advanced diagnostic tools that may be used in cases of unexplained infertility include:

1. Preimplantation Genetic Testing (PGT