Anticoagulants may be used in managing paradoxical embolism in PFO patients to prevent recurrent events, but individual assessment is crucial.

For PFO-related paradoxical embolism, anticoagulation therapy can be considered, especially if there is a high risk of recurrent embolic events.

In patients with PFO and paradoxical embolism, anticoagulants are sometimes recommended, contingent on the risk factors and severity of the embolism.