Amoxicillin can be used in patients with renal impairment, but dosage adjustments are necessary. For those with a creatinine clearance under 30 mL/min, the dosing interval should be extended.

Amoxicillin is safe for patients with renal impairment if dosages are adjusted. For severe impairment (CrCl <30 mL/min), decrease the dose or extend the dosing frequency.

For renal impairment, amoxicillin dosage should be reduced. Patients with a creatinine clearance below 30 mL/min may require less frequent dosing to avoid toxicity.