How does erythromycin differ from other macrolides, such as azithromycin or clarithromycin, in terms of spectrum of activity and clinical applications?
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What is the mechanism by which erythromycin inhibits bacterial protein synthesis and how does this contribute to its antimicrobial effects?
What are the signs and symptoms of an erythromycin overdose and what treatments are recommended to manage potential complications in such cases?
How is erythromycin metabolized and eliminated from the body and what factors, such as liver function, influence its pharmacokinetics and effectiveness?
Can erythromycin be used to prevent infections prophylactically and what conditions or scenarios, such as surgical procedures or exposure to specific bacteria, justify its use for infection prevention compared to alternative antibiotics?
What conditions or patient factors contraindicate the use of erythromycin, such as preexisting liver disease, drug interactions, or cardiac arrhythmias and how can these risks be assessed to ensure patient safety during treatment?
How does erythromycin impact the gut microbiota, potentially leading to dysbiosis or other gastrointestinal issues and what steps can be taken to preserve a healthy microbiome while maintaining effective antibiotic therapy?
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What are the differences between erythromycin base, salts and esters in terms of absorption, stability and clinical applications and how should healthcare providers choose the appropriate form for specific infections?
How is a potential erythromycin allergy diagnosed and can patients outgrow these sensitivities over time, allowing for reintroduction?
What alternatives are available for patients allergic to erythromycin and how do these options compare in efficacy and side effect profiles?