What is the typical adult dosage of Metformin and how does it vary based on factors such as age, weight and severity of type 2 diabetes?
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How does Metformin impact physical exercise performance, including endurance, muscle function and recovery in individuals with or without diabetes?
How does Metformin improve insulin sensitivity and what specific cellular or systemic changes contribute to better glycemic control?
Is Metformin a viable treatment for patients with heart failure and what are the safety and efficacy considerations in this population?
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What are the proper storage conditions for Metformin to ensure its stability and effectiveness, including considerations for temperature, humidity and packaging?
How does Metformin affect appetite regulation and can it contribute to weight loss or changes in dietary habits in patients?
What are the primary contraindications for using Metformin and in which health conditions should its use be avoided or closely monitored?