What role does Metformin play in influencing the long-term risk of cancer recurrence in patients with a history of cancer and what evidence supports these effects?
Gaurav ChauhanContributor
How does Metformin influence the long-term risk of cancer recurrence in patients with a history of the disease?
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Metformin may reduce cancer recurrence by influencing insulin levels and cellular metabolism. Studies, including a meta-analysis in *Diabetologia* (2014), suggest it lowers recurrence rates in breast cancer survivors.
1. Metformin may reduce cancer recurrence in former patients by improving insulin sensitivity and lowering insulin levels, which are linked to tumor growth.
2. Studies suggest metformin lowers recurrence risk in breast cancer survivors by modulating energy metabolism and reducing insulin levels, potentially inhibiting cancer cell growth.