What considerations should be made when prescribing Diphenhydramine to geriatric patients, particularly those with multiple comorbidities or polypharmacy concerns?
Sahil KapoorExplorer
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What considerations should be made when prescribing Diphenhydramine to geriatric patients, particularly those with multiple comorbidities or polypharmacy concerns?
1. Consider reduced dosage due to slower metabolism and increased sensitivity in elderly.
2. Check for potential interactions with existing medications, as polypharmacy increases risks.
3. Assess cognitive function; diphenhydramine may worsen existing confusion or cause delirium.
4. Evaluate renal function; impaired kidneys can lead to higher drug levels and toxicity.
5. Monitor for anticholinergic effects such as dry mouth, constipation, and urinary retention.