How does insulin regulate ketogenesis in the liver and why is this regulation vital for preventing diabetic ketoacidosis?
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How does insulin regulate ketogenesis in the liver and why is this regulation vital for preventing diabetic ketoacidosis?
Insulin suppresses ketogenesis by inhibiting lipolysis in fat cells, which reduces the release of free fatty acids, the substrates for ketone production. This is crucial in preventing the excessive ketone buildup seen in diabetic ketoacidosis.
Insulin inhibits hepatic ketogenesis by reducing the release of fatty acids from adipose tissue and decreasing hepatic fatty acid oxidation. This regulation is essential to avoid the metabolic imbalance and severe acidosis of diabetic ketoacidosis.